Torasemide is one of the most important drugs to prevent water retention (edema) in body tissue caused by heart failure. The active ingredient is also used for acute high blood pressure. It is generally considered to be well tolerated, but can cause disturbances in the electrolyte balance. Pregnant and nursing mothers should avoid taking the active ingredient if possible. Here you can read everything you need to know about torasemide. This is how torasemide works

Torasemid has a diuretic effect, lowers blood pressure and washes out edema (anti-edematous).

In the human body, blood salts (electrolytes such as sodium and potassium) are subject to a delicate balance that is strictly controlled. Electrolytes can be released into or recovered from the urine to be excreted via the kidneys as required. Many different transporters are involved in this delivery and recovery of the electrolytes.

The active ingredient torsemide lasix belongs to the group of loop diuretics. These block a transporter in the kidney that ensures that electrolytes are returned to the body. As a result of the blockage, more electrolytes are excreted in the urine.

This increased amount of salts in the urine also removes water from the body. If a patient has accumulations of water (edema) in the body (e.g. due to a reduced pumping capacity of the heart), loop diuretics such as torasemide can remove water from the body tissue – the tissue swelling is reduced.

In contrast to other diuretics (e.g. thiazides), loop diuretics not only excrete sodium, potassium and chloride ions, but also magnesium and calcium ions.

Uptake, breakdown and excretion

After ingestion by mouth, torasemide is quickly and almost completely absorbed into the blood in the intestine. As a result, the torasemid effect occurs relatively quickly (after about an hour). The active ingredient is broken down in the liver. The resulting breakdown products are mainly excreted via the kidneys.

When is torasemide used?

The areas of application (indications) of torasemide include:

  • Edema as a result of decreased cardiac output (cardiac edema)
  • Pulmonary edema
  • chronic heart failure (heart failure)
  • arterial high blood pressure (hypertension)
  • Increase in urine excretion in the event of poisoning
  • Maintenance of residual diuresis in severe renal insufficiency

This is how torasemide is used

Torasemide is usually given in the form of tablets. Due to its long duration of action, it is enough to take it once a day (in the morning with a little water).

In adults, therapy is usually started with a dose of 5 milligrams (mg) per day. The doctor can increase this daily dose if necessary, for example to 20 mg per day for the treatment of water retention due to heart failure.

Higher daily doses such as 50 mg or 100 mg up to a maximum dose of 200 mg may be necessary in patients with severe renal impairment (common, for example, in dialysis patients with a certain amount of residual excretion).

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